Scientific articles

Kupffer cells are activated in cirrhotic portal hypertension and not normalised by TIPS.

Holland-Fischer P, Grønbæk H, Sandahl TD, Moestrup SK, Riggio O, Ridola L, Aagaard NK, Møller HJ, Vilstrup H..

Gut (in press)

 

Soluble macrophage-derived CD163 is a marker of disease activity and progression in early rheumatoid arthritis.

Greisen SR, Møller HJ, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Jørgensen A, Hvid M, Deleuran B.

Clin Exp Rheumatol. 2011 (in press)

 

Soluble CD163 levels in children with sickle cell disease.

Moller HJ, Nielsen MJ, Bartram J, Dick MC, Height SE, Moestrup SK, Rees DC.

British Journal of Haematology. 2011 Apr;153(1):105-10.

 

Comparative assessment of the recognition of domain-specific CD163 monoclonal antibodies in human monocytes explains wide discrepancy in reported levels of cellular surface CD163 expression.

Maniecki MB, Etzerodt A, Moestrup SK, Møller HJ, Graversen JH

Immunobiology 2011Aug; 216(8): 882-90

 

Serum Soluble CD163 Predicts Risk of Type 2 Diabetes in the General Population.

Møller HJ, Frikke-Schmidt R, Moestrup SK, Nordestgaard BG, Tybjærg-Hansen A.

Clin Chem. 2011 Feb;57(2):291-7

 

Tumor necrosis factor {alpha}-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163.

Etzerodt A, Maniecki MB, Møller K, Møller HJ, Moestrup SK.

J Leukoc Biol. 2010 Dec;88(6):1201-5

 

Hemoglobin and heme scavenger receptors.

Nielsen MJ, Møller HJ, Moestrup SK.

Antioxid Redox Signal. 2010 Feb;12(2):261-73.

 

Soluble macrophage-derived CD163: a homogenous ectodomain protein with a dissociable haptoglobin-hemoglobin binding.

Møller HJ, Nielsen MJ, Maniecki MB, Madsen M, Moestrup SK.

Immunobiology. 2010 May;215(5):406-12.

 

Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging.

Nielsen MJ, Moestrup SK.

Blood. 2009 Jul 23;114(4):764-71

 

Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma.

Jensen TO, Schmidt H, Møller HJ, Høyer M, Maniecki MB, Sjoegren P, Christensen IJ, Steiniche T.

J Clin Oncol. 2009 Jul 10;27(20):3330-7

 

Effect of treatment with human apolipoprotein A-I on atherosclerosis in uremic apolipoprotein-E deficient mice.

Pedersen TX, Bro S, Andersen MH, Etzerodt M, Jauhiainen M, Moestrup SK, Nielsen LB.

Atherosclerosis. 2009 Feb;202(2):372-81.

 

Impaired CD163-mediated hemoglobin-scavenging and severe toxic symptoms in patients treated with gemtuzumab ozogamicin.

Maniecki MB, Hasle H, Friis-Hansen L, Lausen B, Nielsen OJ, Bendix K, Moestrup SK, Møller HJ.

Blood. 2008 Aug 15;112(4):1510-4.

 

A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans.

Vanhollebeke B, DeMuylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E.

Science. 2008 May 2;320(5876):677-81.

 

New immunological serum markers in bacteraemia: anti-inflammatory soluble CD163, but not proinflammatory high mobility group-box 1 protein, is related to prognosis.

Gaïni S, Pedersen SS, Koldkaer OG, Pedersen C, Moestrup SK, Møller HJ.

Clin Exp Immunol. 2008 Mar;151(3):423-31.

 

Trimerization of apolipoprotein A-I retards plasma clearance and preserves antiatherosclerotic properties.

Graversen JH, Laurberg JM, Andersen MH, Falk E, Nieland J, Christensen J, Etzerodt M, Thøgersen HC, Moestrup SK.

J Cardiovasc Pharmacol. 2008 Feb;51(2):170-7.

 

Soluble CD163 from activated macrophages predicts mortality in acute liver failure.

Møller HJ, Grønbaek H, Schiødt FV, Holland-Fischer P, Schilsky M, Munoz S, Hassanein T, Lee WM; U.S. Acute Liver Failure Study Group.

J Hepatol. 2007 Nov;47(5):671-6.

 

A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex.

Nielsen MJ, Petersen SV, Jacobsen C, Thirup S, Enghild JJ, Graversen JH, Moestrup SK.

J Biol Chem. 2007 Jan 12;282(2):1072-9.

 

Macrophage serum markers in pneumococcal bacteremia: Prediction of survival by soluble CD163.

Møller HJ, Moestrup SK, Weis N, Wejse C, Nielsen H, Pedersen SS, Attermann J, Nexø E, Kronborg G.

Crit Care Med. 2006 Oct;34(10):2561-6.

 

Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein.

Nielsen MJ, Petersen SV, Jacobsen C, Oxvig C, Rees D, Møller HJ, Moestrup SK.

Blood. 2006 Oct 15;108(8):2846-9.

 

The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants.

Nielsen MJ, Madsen M, Møller HJ, Moestrup SK.

J Leukoc Biol. 2006 Apr;79(4):837-45

 

Identification of the receptor scavenging hemopexin-heme complexes.

Hvidberg V, Maniecki MB, Jacobsen C, Højrup P, Møller HJ, Moestrup SK.

Blood. 2005 Oct 1;106(7):2572-9.

 

Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome.

Schaer DJ, Schleiffenbaum B, Kurrer M, Imhof A, Bächli E, Fehr J, Moller HJ, Moestrup SK, Schaffner A.

Eur J Haematol. 2005 Jan;74(1):6-10.

 

CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response.

Moestrup SK, Møller HJ.

Ann Med. 2004;36(5):347-54.

 

Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region.

Madsen M, Møller HJ, Nielsen MJ, Jacobsen C, Graversen JH, van den Berg T, Moestrup SK.

J Biol Chem. 2004 Dec 3;279(49):51561-7.

 

Plasma level of the macrophage-derived soluble CD163 is increased and positively correlates with severity in Gaucher's disease.

Møller HJ, de Fost M, Aerts H, Hollak C, Moestrup SK.

Eur J Haematol. 2004 Feb;72(2):135-9.

 

CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma.

Graversen JH, Madsen M, Moestrup SK.

Int J Biochem Cell Biol. 2002 Apr;34(4):309-14.

 

Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma.

Møller HJ, Peterslund NA, Graversen JH, Moestrup SK.

Blood. 2002 Jan 1;99(1):378-80.

 

Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes.

Madsen M, Graversen JH, Moestrup SK.

Redox Rep. 2001;6(6):386-8. Review.

 

Identification of the haemoglobin scavenger receptor.

Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, Moestrup SK.

Nature. 2001 Jan 11;409(6817):198-201.